pentobarbital will lessen the level or impact of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to the decrease in fentanyl plasma concentrations, insufficient efficacy or, potentially, development of a withdrawal syndrome in a affected individual that has designed physical dependence to fentanyl.
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Contraindicated (1)pentobarbital will lower the extent or outcome of elbasvir/grazoprevir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the extent or influence of diclofenac by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unidentified.
pentobarbital will minimize the level or result of conjugated estrogens by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
pentobarbital will reduce the level or effect of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Pitolisant publicity is lowered by 50% if coadministered with strong CYP3A4 inducers.
pentobarbital will minimize the level or effect of diazepam buccal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Potent or average CYP3A4 inducers may well enhance charge of diazepam elimination; consequently, efficacy of diazepam may very well be lowered.
pentobarbital will decrease the level or influence of venetoclax by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
Contraindicated (one)pentobarbital will lessen the level or effect of lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with robust CYP3A4 inducers may result in lessened serum concentrations and loss of antimalarial efficacy
lasmiditan, pentobarbital. Possibly increases effects of the opposite by sedation. Use Warning/Keep track of. Coadministration of lasmiditan and various CNS depressant drugs, which includes Alcoholic beverages haven't been evaluated in clinical scientific tests. Lasmiditan may result in sedation, and other cognitive and/or neuropsychiatric adverse reactions.
pentobarbital will lessen the extent or influence of armodafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unfamiliar.
buprenorphine subdermal implant and pentobarbital both maximize sedation. Keep away from or Use Alternate Drug. Restrict use to sufferers for whom alternative therapy possibilities are insufficient
"There is a extremely basic theory in medicine, primum non nocere, a Latin assertion for 'above all do no harm', so no action that a medical doctor or maybe a surgeon website or a health care provider should consider, must raise the probability of damage.
buprenorphine transdermal and pentobarbital both improve sedation. Keep away from or Use Alternate Drug. Restrict use to sufferers for whom choice procedure choices are inadequate